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Eisenberg T, Knauer H, Schauer A, Bttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Frhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009) Induction of autophagy by spermidine promotes longevity

Each workout produces an acute burst of reactive oxygen species (ROS) in muscle, which paradoxically triggers the cell's defense mechanisms a phenomenon known as mitohormesis ( 3.3 Physical capacity and metabolic health The systemic benefits of exercise in older adults extend to muscle strength, endurance, and metabolism

PMID: 25690343

Do not increase your dose ahead of schedule just because the starting dose feels inactive