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We also showed that the aspirin-induced apoptosis in redox-compromised MnSOD-deficient yeast cells is associated with severe mitochondrial dysfunction, including events such as overproduction of mitochondrial superoxide radicals (O 2 ), oxidation of mitochondrial NAD(P)H 21 , decreased respiration, release of cytochrome c and disruption of the mitochondrial membrane potential 20

van der Brug MP, Blackinton J, Chandran J, Hao LY, Lal A, Mazan-Mamczarz K, Martindale J, Xie C, Ahmad R, Thomas KJ, et al: RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways