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In parallel, excessive mtROS serve as potent activators of the NLRP3 inflammasome, promoting caspase-1 activation and the maturation of IL-1 and IL-18 [99, 100]
A newer analysis of two multi-center clinical studies of subjects with type I or type II diabetes showed that oral treatment with acetyl-L-carnitine (3000 mg/day) over a period of one year provided significant relief from nerve pain as well as improved vibration perception in patients with diabetic neuropathy
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