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The reaction was terminated by the addition of 400 L phase A (0.1% trifluoracetic acid) before being fractionated into 1 mL volume by reverse-phase high-performance liquid chromatography (RP-HPLC, Waters 600 SimiPrep system) on a C18 column

In these 3 adult studies, LANTUS and NPH insulin had similar effects on HbA1c (Table 9) with a similar overall rate of severe symptomatic hypoglycemia [see Adverse Reactions (6.1)]

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PARP-1, the enzyme the body relies on to repair damaged DNA, can no longer work at full capacity