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1b and c)
Chemical Defense therapeutic area(s) including key possible uses Hydroxocobalamin is indicated as an antidote in patients with known or suspected cyanide poisoning
1 According to poison centers in the United States, acetaminophen poisoning was responsible for more than 70,000 visits to health care facilities and approximately 300 deaths in 2005
The hepatotoxicity of APAP rests predominantly with the highly toxic and reactive compound NAPQI, which forms covalent bonds with sulfhydryl groups on cysteine and lysine molecules within the mitochondria of hepatocytes and which spontaneously reacts with GSH and binds to hepatic proteins.8,11 The protein adducts formed, specifically those of mitochondrial protein adducts, lead to oxidative injury and hepatocellular necrosis
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