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A crucial observation was that DSIPs activating effect on oxidative phosphorylation was selective, primarily increasing V3 without affecting VDNP, and showing no evidence of uncoupling oxidative phosphorylation

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With their assistance, cystine is absorbed into cells and rapidly reduced to cysteine, participating in the synthesis of intracellular GSH (Ursini and Maiorino, 2020) (Figure 4)