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N Engl J Med 392(5):427437 Pratley RE, Tuttle KR, Rossing P, Rasmussen S, Perkovic V, Nielsen OW et al (2024) Effects of semaglutide on heart failure outcomes in diabetes and chronic kidney disease in the FLOW trial

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Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]