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Unlike some peptides that require cycling to prevent receptor desensitization, AOD-9604 does not appear to lose efficacy with continuous use based on available data

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In vitro studies demonstrate that a critical GH responsive transcription factor, signal transducer and activator of transcription-5b, is maximally activated by pulsatile GH delivery, whereas continuous GH delivery decreases signal transducer and activator of transcription-5b activation to 1020% of the maximal level (35,36)