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Current research predominantly focuses on preclinical models, with limited clinical translation due to heterogeneous tumor biology and inconsistent pharmacokinetic outcomes [8]
Meanwhile, endothelial dysfunction compounds these effects by impairing vasodilation, increasing arterial stiffness, and promoting thrombosis, ultimately heightening the risk of hypertension and microvascular ischemia (118)
Mistake 5: Contamination from poor technique Touching the needle tip, failing to swab the vial stopper, or reconstituting in an unclean environment all introduce bacteria
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