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The most commonly reported side effects are mild and include a temporary increase in hunger (related to its ghrelin receptor activity), mild water retention during the initial weeks, tingling or numbness in the extremities, and occasional headache

The WT mice had considerably less DNA adducts (molecules that are strongly bonded to DNA that can lead to DNA breaks and mutations) than the KO mice

Common injection areas include the abdomen , upper arm , and outer thigh (rotate sites regularly)

Microdosing tirzepatide in units Microdosing has gained significant attention as a strategy for minimizing side effects while still receiving therapeutic benefit