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Hypothyroidism-induced metabolic and oxidative stress disrupts the homeostatic regulation of ECM turnover by MMP and their inhibitor (TIMP), promoting pathological cross-linking, stiffness, and matrix accumulatio (125)

GLP-1 RAs or sodium-dependent glucose transporter 2 (SGLT2) inhibitors are often recommended for patients with T2DM who have atherosclerotic cardiovascular disease (ASCVD) or indicators of high risk for it due to the cardiovascular benefits they provide (American Diabetes Association, 2021)

Liposomal formats help maintain this stability

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