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More recently, the same residue was mutated back to a non-acidic residue uniquely in legume plants, which resulted in prephenate-specific TyrA p enzymes (Schenck et al., 2017)

92 showed that enzymatically increasing the NADH-to-NAD + conversion exclusively in the mitochondria of HeLa cells improves ETC function, highlighting the importance of maintaining high NAD + levels