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To overcome these limitations, this review discusses a range of structural modifications, including N-terminal and C-terminal substitutions, fatty acid conjugation, and large molecule fusion technologies, which have collectively contributed to enhanced half-life, increased stability, improved receptor affinity, and retained or augmented bioactivity of GLP-1 analogs

The difference is that the retatrutide effect is sustained rather than transient

Although the detailed mechanisms underlying the differential effects of SCFAs on asthma pathophysiology remain unclear, their clinical impact on asthma severity, especially in patients with obesity, should be carefully evaluated

Diabetologia 54 , 22632271 (2011)