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LSN3160440 is a positive allosteric modulator of the GLP-1R optimized to increase the affinity and efficacy of GLP-1(9-36), a proteolytic product of GLP-1(7-36)

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L-carnitine dependent binding of the purified CarR protein to the intergenic region between carR and the consecutive carnitine catabolic operon was demonstrated (Breisch et al., 2022)

6,15,16 Taken together, the appropriate length is between C16 and C20 and most suitable lipidation position can be chosen from the following range of positions (starting from position 1): 10, 16, 20, 21, 28, and C-terminal