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[1] [2] Hydroxocobalamin is a prescription-only medicine (POM) that should be administered by appropriately trained healthcare professionals, typically following a standard regimen of loading doses (e.g., 1mg on alternate days for 1-2 weeks) followed by maintenance doses (1mg every 2-3 months, or every 2 months if neurological symptoms are present)

Brain function relies on the SAM pathway that involves MTR function