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Specifications Reported Side Effects in Research Mild injection site irritation and transient redness reported in clinical studies Theoretical copper toxicity risk at very high doses, though not observed at standard research concentrations Mild skin sensitivity reported in some topical application studies This product is intended strictly for laboratory and research purposes only

Patients were also excluded if they met the ASA physical status classification of ASA 4 (patients with severe systemic disease threatening life) or ASA 5 (patients who were not expected to survive without surgery) (Figure 1)

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