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Description

The effects of SIRT3 are through deacetylation and activation of the stress responder FOXO3

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2 REDEFINE 2 was a double-blind, randomized, placebo-controlled 68-week phase 3 trial that evaluated the efficacy and safety of once-weekly CagriSema versus placebo, both along with lifestyle intervention in 1,206 adults with type 2 diabetes and either obesity or overweight

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Understanding where this field is heading helps contextualize the current choice between these two agents

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Reduced activity level: Bothersome fatigue, nausea, or other side effects of Ozempic can make it challenging to stay active

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