Symptoms, which are variable, include hair loss, weight gain, fatigue, low energy, constipation, as well as muscle weakness
And one nutrient takes a particularly hard hit: vitamin B12
Our findings align with these previous studies, leading us to hypothesize that GSH levels are higher in the tumor tissues of chemotherapy-resistant breast cancer patients compared to chemotherapy-sensitive patients
Mechanistically, TNF- induces SLC7A11 and the glutamate-cysteine ligase modifier subunit by activating nuclear factor-B (NF-B), which upregulates the regulatory subunit of glutamate-cysteine ligase catalytic (GCLC) and glutamate-cysteine ligase catalytic, ultimately enhancing cellular GSH biosynthesis and protecting against lipid peroxidation-induced stress, thereby increasing ferroptosis resistance (89)