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The most common reason cause of the Jarisch-Herxheimer Reaction are taking high doses of antifungals or antibiotics, but the condition can also occur when rapid changes of diet cause large-scale die-off of gut microflora overgrowth (also see: SIBO Diet)

The evidence base is not human clinical data, but it is far more extensive than KPV's body of work

However, the source paper contains inconsistent descriptions of the SPR concentration rangethe figure legend specifies 23.4496,000 nM, whereas the methods section lists 1.8931.25 nM, a discrepancy of several thousand-fold

Unscheduled labs should be triggered by symptoms not calendar alone