With Contrave, an overdose can cause seizures, hallucinations, loss of consciousness, heart problems, fever, muscle rigidity, muscle breakdown, low blood pressure, respiratory failure, and coma
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It explains why folate supplementation (particularly with 5-MTHF rather than folic acid in T/T individuals) improves endothelial function and reduces arterial stiffness in published clinical trials effects that operate partly through homocysteine lowering and partly through BH4 recycling restoration and improved eNOS coupling efficiency