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However, passive targeting lacks specificity, leading to non-specific accumulation in normal tissues, which can cause side effects

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IGF-1 LR3 IGF-1 LR3 is a modified recombinant insulin-like growth factor 1 analogue of 83 amino acids synthesised with an N-terminal extension and Arg3 substitution, studied in anabolic signalling research for its role in increasing the free fraction of circulating IGF-1 (~3 vs native)