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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Employing HITI for in vivo knock-in of large DNA fragments, we designed a guide RNA (gRNA) targeting exon 14 of the Alb gene (sgAlb-E14), which has demonstrated efficient ectopic gene integration via genome editing 20

A randomized, double-blind, crossover study involving 30 patients demonstrated that nitroglycerin patches significantly reduced pain severity compared with placebo [153]