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L-carnitine, they concluded, appeared to be safe, well-tolerated and positively influenced exercise capacity and respiratory muscle strength in COPD patients. The National Institutes of Health (NIH) According to the NIH, Supplements do not appear to increase the bodys use of oxygen or improve metabolic status when exercising, nor do they necessarily increase the amount of carnitine in muscle. Although the NIH says that, as a therapy, carnitine is generally safe and well tolerated, carnitine supplements can lead to some unwanted effects