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Scott, MD, MPH, and Bennie H

9 Additionally, although an intensive lifestyle intervention for WL in the Look AHEAD: Action for Health in Diabetes (LookAHEAD) trial did not show reduction in major adverse cardiovascular events (MACE-4) in people with T2DM and obesity compared to a diabetes education and support program, a post hoc analysis demonstrated that those who lost 10% of their baseline body weight during the first year of the trial had a 21% lower risk for cardiovascular events over a 10 years follow-up period compared to those with stable weight or weight gain

GIP receptor activation does not produce the nausea and gastrointestinal distress that limits GLP-1 receptor dose escalation

Flashes of very hot or cold temperature Changes to appetite and/or weight Dizziness Fatigue Headaches Safety BPC-157 is generally considered safe for use