Retatrutides higher discontinuation rate due to adverse events, combined with the dysesthesia signal, places a greater tolerability burden on participants compared to tirzepatide [3]
The STEP 1 extension trial showed participants regained about two-thirds of lost weight within a year of stopping semaglutide (Wilding et al., 2022)
Once applied, these microneedles dissolve naturally , releasing GLP-1 in a steady, controlled manner over time without the spikes or dips often seen with injections
GLP-1s offer significant promise to millions of Americans living with obesity, diabetes and/or cardiovascular disease, but their unprecedented demand and high price tags are creating challenging downstream impacts, including fluctuating supply, inconsistent clinical support, and runaway cost trajectory, said an Evernorth statement