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In doing so, we detected extensive changes pertaining to glutathione synthesis ( GCLC , GCLM , GLUL , GLS2 , SLC3A2 , SLC7A11 ), iron regulation ( FTH1 , FTL1 , TFRC ), lipid metabolism ( ACSL1 , ACSL3 , ACSL4 , AGPAT3 , CARS , SQSTM1 ), redox homeostasis ( DHODH , KEAP1 , POR , AIFM2 , GCH1 , NFE2l2 , NQO1 , and TXNRD1 ), and other ferroptosis-related pathways in both YR1.7 and MC38 following treatment with simvastatin (Figure 3C)

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Microglial remodeling of the extracellular matrix promotes synapse plasticity

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