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However DO NOT take higher than dose stated or use without medical supervision (especially in case of fluid overload related conditions such as cardiomyopathy, congestive heart failure, cerebral edema, chronic kidney disease, use of nitrates and related cardiovascular drugs, etc.)

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Diabetic patients who were older and/or had had a stroke had an even higher risk of developing macular degeneration if they were on these drugs, the authors found

Suppose you notice blood in your stool, changes in vision, or symptoms of pancreatitis, such as severe abdominal pain that radiates to your back and is accompanied by vomiting