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Most patients experience their first side effects between one and three days after starting treatment, though the timing and intensity vary based on individual metabolism and genetic factors

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Achieving these stringent endpoints, as outlined in the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) consensus ( Research into mucosal healing has highlighted pathways involving interleukin-20 (IL-20), claudin-2 (CLDN2), and notoginsenoside R1 (NGR1) ( Figure 1 illustrates the differences in immune cell distribution within the intestinal crypts under homeostatic conditions compared with the inflammatory microenvironments of CD and UC

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Castro-Marrero J, Cordero MD, Sez-Francas N, et al

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