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Abbreviations MSM: methyl sulphonyl methane Vit C: vitamin C GPx: glutathione peroxidise GST: glutathione transferase GR: glutathione reductase HO: heme oxygenase ROS: reactive oxygen species RNS: reactive nitrogen species NO: nitric oxide CO: carbon monoxide GSH: glutathione

During surgery, damaged or ischemic cells release a flood of intracellular contents (so-called damage-associated molecular patterns, DAMPs), which activate the same innate immune receptors that sense pathogens (4)

Leptin is considered to be a good predictor of growth hormone (GH) burst, cortisol, estradiol, and thyroid hormone levels and its receptor is widely distributed throughout the body suggesting a pivotal role in mediating the hormonal adaptation to chronic starvation

PIONEER 3 Investigators