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Aged mice (22 months, equivalent to roughly 65 to 70 human years) treated with MOTS-c three times per week doubled their running capacity on treadmill tests

Dietary deficiency: Vegans (strict vegetarians who do not eat any meat, fish, egg, or dairy products) can develop vitamin B 12 deficiency because they lack vitamin B 12 in their diets

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in the UK, hydroxocobalamin is standard, typically given as a loading dose (e.g., 1 mg on alternate days for about 2 weeks), then 1 mg every 3 months (or every 2 months if neurological involvement is present) The NHS and The Vegan Society recommend that individuals at risk of deficiency, particularly vegans and older adults, consider regular B12 supplementation