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In both diabetic mice and high-glucose stimulated HK-2 cells, empagliflozin has been shown to enhance phosphorylation of AMPK at Thr172, which in turn promotes nuclear translocation of NRF2 (Lu et al., 2023)

FDA Safety Announcement: Rybelsus FDA Safety Label Change and Revised Drug LabelThe revised drug label contains a complete list of FDA-approved indications, side effects, warnings, and more