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10.3389/fphar.2019.00252 222 RegelmannW

The previous hypothesis was that if these GLP-1s could reduce [adverse cardiovascular] events in people with diabetes because of their anti-inflammatory properties, they could do the same in people without diabetes, explains Cristbal Morales, an endocrinologist at the Virgen de la Macarena Hospital in Seville, Spain, and the studys national coordinator

Based on the flow of these studies, it can be observed that they were not limited to -amino acids, but continuously screened for the difference in the permeability enhancing effect according to the changes in the substituents of N-acylated-non--amino acid, lipophilicity, etc