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By demonstrating protective effects in a ciliopathy model, this study suggests that GLP-1 RAs may confer benefits beyond appetite suppression in patients with genetic obesity syndromes affecting ciliary function, further broadening the mechanistic rationale for targeting this pathway across diverse genetic etiologies of obesity

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Treatment with FOXO4-DRI following chemotherapy exposure potently counteracts these effects, normalizing body weight and reducing plasma AST to near-baseline levels

MITOCHONDRIAL ROS GENERATION AND DEFENSE Reactive oxygen species can be generated in several intracellular sites, including cytosol, peroxisomes, plasma membrane, and ER