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Due to the increased methylation in the GAD1 promoter region, the binding of the transcriptional repressor MeCP2 is enhanced, resulting in downregulation of gene expression

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As we move forward, personalizing microbiome therapies will likely be necessary for instance, stratifying patients by their microbiome profile or metabolite levels, then tailoring the intervention (one patient might need more SCFAs, another needs more anti-TMAO measures, etc.)