doi: 10.1111/cpr.13644 114 HsiehMYHsuSKLiuTYWuCYChiuCC
Studies in mice and humans show that innate and adaptive immune responses, involving macrophages, neutrophils, natural killer cells, B and T lymphocytes, should control the parasite through the production of ROS/RNS, proinflammatory T H 1 cytokines, trypanolytic antibodies, and cytotoxic T lymphocytes' activity
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NADPH, generated through glutamine metabolism, supports glutathione regeneration, helping keep ROS levels in check