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Dai et al., 2024)

Notably, the enzymatic activity of GPX4 is strictly dependent on its active-site selenocysteine residue (168), implying that dietary selenium intake directly regulates GPX4 protein expression and functional activity, thereby determining cellular susceptibility to ferroptosis

Oral copper supplementation is an effective way to treat deficiency: the recommended dose is 1.53 mg once or twice a day for 3 months

The remarkable weight loss and glucose-lowering results achieved by the dual peptides paved the way for triple GIP/GLP-1/glucagon receptor triagonists with the hope that the new combinatorial approaches provide further synergistic metabolic effects