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Importantly, GLPs exert gut-heart axismediated benefits by selectively enriching SCFA-producing bacterial taxa, boosting colonic SCFA bioavailability, and suppressing hepatic TMAO synthesisthereby mitigating key drivers of diabetic cardiomyopathy progression

These include ferroptosis suppressor protein 1(FSP1)/CoQ10, GTP cyclohydrolase1 (GCH1)/tetrahydrobiopterin (BH4), and dihydroorotate dehydrogenase (DHODH) ( Figure 1 )

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Atlanta: Centers for Disease Control and Prevention