Salidroside showed no obvious toxicity in rats after repeated administration for 7 and 28 days (500, 1,000, 2000 mg/kg) and no clinical adverse events in humans at 600 mg/day (Kasprzyk et al., 2022
Always establish baseline oxidative stress biomarkers and discuss timing, dose, and formulation (oral, liposomal, or S-acetyl) with a qualified healthcare provider before initiating or adjusting glutathione protocols
Even further, preliminary researches point to Glutathione preventing some of the cancers, while higher intake can improve the health of older adults
Some people, including some individuals with Hashimotos, have the MTHFR gene variation that prevents them from properly processing the folic acid that may be present in less expensive supplements and processed foods