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ArGLP-1 also reduced total mortality (HR 0.88, 95% CI 0.820.94, p = 0.0001) and hospital admission due to heart failure (HR 0.89, 95% CI 0.820.98, p = 0.013), all without increasing the risk of severe hypoglycemia, pancreatic problems or retinopathy.87 A recent post hoc analysis of CVOT with semaglutide has shown a gain in time free of cardiovascular disease of 1.7 years in those patients with CKD vs

Future perspectives In summary, the cardiovascular safety of all currently marketed GLP-1 RAs has been thoroughly established in large CVOTs (Sattar et al., 2021), of which some also suggested a substantial cardioprotective benefit

Formation of Short Chain Fatty Acids by the Gut Microbiota and Their Impact on Human Metabolism