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doi: 10.1016/j.biopha.2024.116690

Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Absent Core Comorbidities: Absent Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility with skin involvement Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Present Core Comorbidities: Absent Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility with core comorbidities Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Absent Core Comorbidities: Present Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility with core comorbidities and with skin involvement Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Present Core Comorbidities: Present Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, musculoskeletal subtype Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Absent Core Comorbidities: Absent Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, musculoskeletal subtype with skin involvement Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Present Core Comorbidities: Absent Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, systemic subtype Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Absent Core Comorbidities: Present Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, systemic subtype with skin involvement Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Present Core Comorbidities: Present Vascular EDS (vEDS) Genetic testing is used to see if a person has a genetic variant that causes vEDS

Similarly, ~0.4 kb DNA downstream (3 flank) of the open reading frame (ORF) was amplified by PCR of genomic DNA using primers P3 and P4

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