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Since the E2F1-pRb-CDK4 pathway positively modulates the expression of Ccna2 and Ccnd1 (68), our data suggest that the cell cycle progression of pancreatic cell through the induction of Ccna2 and Ccnd1 with exendin-4 treatment could be associated with an increase of E2f1 expression and/or activity

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In clinical trials, it was found to control blood sugar levels in adults with type 2 diabetes by stimulating insulin, reducing glucagon, and slowing digestion