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Insulin resistance is a hallmark of T2DM, leading to down-regulation of insulin signaling pathways (at the post-receptor level) in these tissues [139]

Given the surging popularity of obesity management drugs in recent years, the FDA put out a warning singling out compounded GLP-1s, calling them risky for patients. The agency said it had received hundreds of reports of adverse events linked to compounded semaglutide (392) and tirzepatide (215) as of Nov

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2.3 Intersection gene screening and functional enrichment analysis To explore potential associations among gut microbiota, ferroptosis, and RA, Venn diagram analysis was performed on gut microbiota-related genes, ferroptosis-related genes, and RA-related genes to identify intersection genes