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Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of Toll-like receptor 4 signaling

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Supplement Facts: Serving Size: 1-2 capsules Servings Per Container: 60-30 Amount Per Serving: Conjugated linoleic acid (CLA) 80%: 1000 mg (of which CLA 800 mg) Green tea extract: 400 mg (of which EGCG 132 mg) L-carnitine: 200 mg *RI - Reference Intake Ingredients: 37% conjugated linoleic acid CLA, 14.8% green tea extract, soybean oil , 7.4% L-carnitine, capsule (gelatine, glycerin, water, colour: E172) Recommended Use: Take 1-2 capsules two times daily after breakfast and approximately 30 minutes before physical activity

Under normal conditions, the gut microbiota and the gut barrier maintain immune homeostasis by distinguishing between commensal bacteria and pathogens, thereby regulating PRR expression and preventing excessive inflammation (Pan et al., 2023)