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Comment: A commenter expressed concern regarding the measure's feasibility as CMS requires a minimum random sample size of 200 completed surveys and asked for clarification regarding the proposal for the minimum random sample size

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Key mechanistic features: Selective GHSR-1a agonism Potent GH release without cortisol/ACTH/prolactin elevation Gq/11 Ca signalling Intracellular calcium rise triggers GH exocytosis Pulsatile GH release Preserves physiological GH pulse pattern