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This contrasts with pseudoephedrine which has a bioavailability close to 100% (Kanfer et al 1993

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Because yerba mate contains a decent amount of caffeine, drinking too much of it can also cause some of the side effects associated with excess caffeine intake, such as jitteriness, insomnia, increased heart rate, and elevated blood pressure

For individuals with low G6PD activity, it may be beneficial to focus on consistent, moderate-intensity movement rather than pushing to the point of exhaustion, which can deplete your antioxidant stores quickly