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(44(3)):406-410 doi:10.1111/jvp.12967

- ,

The central nervous system theory focuses on brain effects

Pharmacokinetics: Data indicate a linear pharmacokinetic profile with a short half-life ( 1000mcg/day) have been anecdotally associated with increased chances of headaches, fatigue, or water retention, and may lead to diminishing returns, suggesting a bell-shaped dose-response curve