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The energy cost resulting from bilayer bending is described by (where u ( x , y ) describes local spatial deviations of the bilayer center in the out-of-plane direction, is the membranes bending modulus, and A is the area covered by the membrane

Simulation set-up The MD simulations of wild-type p97-ND1L in the ADPP i state and point mutations thereof (N348Q, R359K, F360P) were started from the crystal structure with PDB 4KO8 (ref

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