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Abbreviations ALT: Alanine transaminase AST: Aspartate transaminase RPM: Revolutions per minute H&E: Hematoxylin-eosin LC-MS/MS: Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) QQQ: Triple quadrupole QTRAP: A triple quadrupole-linear ion trap mass spectrometer KEGG: Kyoto encyclopedia of genes and genomes MSEA: Metabolite sets enrichment analysis MPO: Myeloperoxidase PCA: Principal component HCA: Hierarchical cluster analysis PCC: Pearsons correlation coefficients POD: Postoperative day References Michalopoulos GK, Bhushan B