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If rapid weight loss is accompanied by significant declines in strength or energy, its worth reviewing medication dosage, diet, and exercise programming with a healthcare professional, says Enaz.

This side effect is not unique to GLP-1s, as rapid weight loss from any cause can increase the risk of developing gallstones

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For each comparison in both the class-level and agent-level networks, six domains were evaluatedwithin-study bias, reporting bias, indirectness, imprecision, heterogeneity, and incoherenceand an overall confidence rating (high, moderate, low, or very low) was assigned