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During the titration phase (weeks 1-20), participants often see gradual weight loss of 1-2 pounds per week as doses are increased, reduced appetite and food cravings within the first 2-4 weeks, improved satiety and easier adherence to reduced-calorie diets, and early body gains (better glucose control, reduced blood pressure)

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Thus, the data from this study support the notion that BH4 can improve oxidative damage and methylation abnormalities in children with ASD with a large effect size, with the caveat that this effect may be more pronounced in those with the more severe abnormalities at baseline

The Se levels of the subjects in this study were inferred from the diet, so it has an information bias